Steroid hormones act in specific regions of the brain to alter behavior and physiology. While it has been well established that the bioavailability of the steroid and the expression of its receptor is critical to understanding steroid action in brain, the importance of nuclear receptor coactivators in brain is becoming more apparent. This review will focus on the function of the p160 family of coactivators, which includes steroid receptor coactivator-1 (SRC-1), SRC-2 and SRC-3, in steroid receptor action in brain. The expression, regulation and function of these coactivators in steroiddependent gene expression in brain and behavior will be discussed.
Tetel, Marc J., and Acharya, and Kalpana D. Nuclear receptor coactivators: Regulators of steroid action in brain and behavior, J Neuroendocrinol. 2013 November ; 25(11): 1209–1218. doi:10.1111/jne.12065.