Date

2017

Department or Program

Biological Chemistry

Primary Wellesley Thesis Advisor

Dora Carrico-Moniz

Abstract

A coumarin derivative, DCM-MJ-I-21 has shown promising antineoplastic effects against human pancreatic adenocarcinoma cells, PANC-1, with higher cytotoxicity and nutrient-deprived selectivity. Commercially available chemotherapeutic drugs used in the treatment for pancreatic cancer patients include gemcitabine (GEM) and 5-fluorouracil (5-FU), both DNA synthesis inhibitors. With the increasing resistance to chemotherapy drugs and the nature of pancreatic cancer growth, promising studies have shown more effective treatments with combination chemotherapy where drugs are taken simultaneously in a regimen. The research presented herein includes both ongoing monotherapy and combination therapy studies against PANC-1 monolayer cells on the cytotoxicity of a chemotherapeutic treatment when commercially available drugs are combined with DCM-MJ-I-21.

Available for download on Wednesday, April 20, 2022

Share

COinS